TMS vs Traditional Treatment Options

Brainsway Deep TMS vs. Antidepressants for Major Depressive Disorder Efficacy

In the NIH-sponsored STAR*D study (Sequenced Treatment Alternatives to Relieve Depression)  it was found that 63.2% of patients suffering from major depression fail to benefit from the first line of antidepressant treatment. 33% of patients do not respond to any drug treatment.1

Brainsway Deep TMS was tested in patients who failed to benefit from at least one antidepressant, and was found effective even for patients who failed to benefit from several prior antidepressant medications2

It is noteworthy that in real-life clinical practice settings, many patients receive Deep TMS therapy concomitantly with antidepressants.  Continued antidepressant use is not contraindicated in patients receiving Deep TMS.

Brainsway Deep TMS vs. ECT for Major Depressive Disorder

While ECT is considered to be very effective for severe, treatment-resistant depression, no multicenter trial was conducted to evaluate the effectiveness of ECT in the treatment of major depression. It also has some downsides. Many patients do hesitate undergoing ECT (Electro convulsive therapy) due to the side effects, anesthesia and hospitalization that might be required.

Deep TMS therapy, was tested in a large, multicenter trial. And showed to be effective for patients with severe depression.

References:
1. Rush AJ, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006;163:1905–1917.
2. Levkovitz Y. et al. Efficacy and safety of deep transcranial magnetic stimulation for major depression: a prospective, multi-center, randomized, controlled trial. World Psychiatry, 2015; Vol.14, 64-73.
3. Levkovitz Y, Harel EV, Roth Y, Braw Y, Sheer A Katz L, Gersner R and Zangen A. (2009) Deep transcranial magnetic stimulation of the prefrontal cortex – Effectiveness in major depression. Brain Stimulation2: 188-200.
4. Isserles M, Rosenberg O, Dannon P, Lerer B and Zangen A (2011) Cognitive emotional reactivation during deep transcranial magnetic stimulation over the prefrontal cortex of depressive patients affects antidepressant outcomes. Journal of Affective Disorders 128: 235-242.
5. Harel EV, Rabany L, Deutsch L, Bloch Y, Zangen A, Levkovitz Y. H-coil repetitive transcranial magnetic stimulation for treatment resistant major depressive disorder: An 18-week continuation safety and feasibility study. World J Biol Psychiatry 2014;15(4):298-306.
6. Fabbri C, Marsano A, Balestri M, De Ronchi D, Serretti A. Clinical features and drug induced side effects in early versus late antidepressant responders. J Psychiatr Res 2013;47(10):1309-1318.
7. Lawrence Park, AM, MD. (2011). Risks and Side Effects of ECT. Psych Central. Retrieved on December 3, 2014, from http://psychcentral.com/lib/risks-and-side-effects-of-ect/0007365
8. O’Reardon JP, Solvason HB, Janicak PG, et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry 2007;62:1208-1216.
9. George MS, Lisanby SH, Avery D, et al. Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial.  Arch Gen Psychiatry 2010;67:507-516.